Today, we’re talking about building real AI products with foundation models. Not toy demos, not vibes. We’ll get into the boring dashboards that save launches, evals that change your mind, and the shift from analyst to AI app builder. Our guide is Hugo Bowne-Anderson, educator, podcaster, and data...

   Building a UI in Python usually means choosing between quick and limited or powerful and painful. What if you could write modern, component-based web apps in pure Python and still keep full control? NiceGUI, pronounced Nice Guy sits on FastAPI with a Vue Quasar front end, gives you real components,...

   Python in 2025 is different. Threads really are about to run in parallel, installs finish before your coffee cools, and containers are the default. In this episode, we count down 38 things to learn this year: free-threaded CPython, uv for packaging, Docker and Compose, Kubernetes with Tilt, DuckDB...

   Python typing got fast enough to feel invisible. Pyrefly is a new, open source type checker and IDE language server from Meta, written in Rust, with a focus on instant feedback and real-world DX. Today, we will dig into what it is, why it exists, and how it plays with the rest of the typing...

   Today we’re turning tiny tips into big wins. Khuyen Tran, creator of CodeCut.ai, has shipped hundreds of bite-size Python and data science snippets across four years. We dig into open-source tools you can use right now, cleaner workflows, and why notebooks and scripts don’t have to be enemies. If...

   English is now an API. Our apps read untrusted text; they follow instructions hidden in plain sight, and sometimes they turn that text into action. If you connect a model to tools or let it read documents from the wild, you have created a brand new attack surface. In this episode, we will make that...

   A couple years ago, Charlie Marsh lit a fire under Python tooling with Ruff and then uv. Today he’s back with something on the other side of that coin: pyx. Pyx isn’t a PyPI replacement. Think server, not just index. It mirrors PyPI, plays fine with pip or uv, and aims to make installs fast and...

   Today on Talk Python: What really happens when your data work outgrows your laptop. Matthew Rocklin, creator of Dask and cofounder of Coiled, and Nat Tabris a staff software engineer at Coiled join me to unpack the messy truth of cloud-scale Python. During the episode we actually spin up a 1,000...

   Twenty years after a scrappy newsroom team hacked together a framework to ship stories fast, Django remains the Python web framework that ships real apps, responsibly. In this anniversary roundtable with its creators and long-time stewards: Simon Willison, Adrian Holovaty, Will Vincent, Jeff...

   Agentic AI programming is what happens when coding assistants stop acting like autocomplete and start collaborating on real work. In this episode, we cut through the hype and incentives to define agentic, then get hands-on with how tools like Cursor, Claude Code, and LangChain actually behave...

   Python’s data stack is getting a serious GPU turbo boost. In this episode, Ben Zaitlen from NVIDIA joins us to unpack RAPIDS, the open source toolkit that lets pandas, scikit-learn, Spark, Polars, and even NetworkX execute on GPUs. We trace the project’s origin and why NVIDIA built it in the open,...

   What if your code was crash-proof? That’s the value prop for a framework called Temporal. Temporal is a durable execution platform that enables developers to build scalable applications without sacrificing productivity or reliability. The Temporal server executes units of application logic called...

   Every year the core developers of Python convene in person to focus on high priority topics for CPython and beyond. This year they met at PyCon US 2025. Those meetings are closed door to keep focused and productive. But we’re lucky that Seth Michael Larson was in attendance and wrote up each topic...

   Why do people listen to this podcast? Sure, they’re looking for technical explorations of new libraries and ideas. But often it’s to hear the story behind them. If that speaks to you, then I have the perfect episode lined up. I have Barry Warsaw, Paul Everitt, Carol Willing, and Brett Cannon all...

   Do you like to dive into the details and intricacies of how Python executes and how we can optimize it? Well, do I have an episode for you. We welcome back Brandt Bucher to give us an update on the upcoming JIT compiler for Python and why it differs from JITs for languages such as C# and Java....

   If you’re doing data science and have mostly spent your time doing exploratory or just local development, this could be the episode for you. We are joined by Catherine Nelson to discuss techniques and tools to move your data science game from local notebooks to full-on production workflows. Episode...

   Are you using Polars for your data science work? Maybe you’ve been sticking with the tried-and-true Pandas? There are many benefits to Polars directly of course. But you might not be aware of all the excellent tools and libraries that make Polars even better. Examples include Patito which combines...

   If you’re looking to leverage the insane power of modern GPUs for data science and ML, you might think you’ll need to use some low-level programming language such as C . But the folks over at NVIDIA have been hard at work building Python SDKs which provide nearly native level of performance when...

   If you’ve heard the phrase Automate the boring things for Python, this episode starts with that idea and takes it to another level. We have Glyph back on the podcast to talk about Programming YOUR computer with Python. We dive into a bunch of tools and frameworks and especially spend some time on...

   If you want to leverage the power of LLMs in your Python apps, you would be wise to consider an agentic framework. Agentic empowers the LLMs to use tools and take further action based on what it has learned at that point. And frameworks provide all the necessary building blocks to weave these into...

   The folks over at Astral have made some big-time impacts in the Python space with uv and ruff. They are back with another amazing project named ty. You may have known it as Red-Knot. But it’s coming up on release time for the first version and with the release it comes with a new official name: ty....

   See the full show notes for this episode on the website at talkpython.fm 505

   See the full show notes for this episode on the website at talkpython.fm 504

   See the full show notes for this episode on the website at talkpython.fm 503

   See the full show notes for this episode on the website at talkpython.fm 502

   See the full show notes for this episode on the website at talkpython.fm 501

   See the full show notes for this episode on the website at talkpython.fm 500

   See the full show notes for this episode on the website at talkpython.fm 499

   See the full show notes for this episode on the website at talkpython.fm 498

   See the full show notes for this episode on the website at talkpython.fm 497

   See the full show notes for this episode on the website at talkpython.fm 496

   See the full show notes for this episode on the website at talkpython.fm 495

   See the full show notes for this episode on the website at talkpython.fm 494

   See the full show notes for this episode on the website at talkpython.fm 493

   See the full show notes for this episode on the website at talkpython.fm 492

   See the full show notes for this episode on the website at talkpython.fm 491

   See the full show notes for this episode on the website at talkpython.fm 490

   See the full show notes for this episode on the website at talkpython.fm 489

   See the full show notes for this episode on the website at talkpython.fm 488

   See the full show notes for this episode on the website at talkpython.fm 487

   See the full show notes for this episode on the website at talkpython.fm 486

   See the full show notes for this episode on the website at talkpython.fm 485

   See the full show notes for this episode on the website at talkpython.fm 484

   See the full show notes for this episode on the website at talkpython.fm 483

   See the full show notes for this episode on the website at talkpython.fm 482

   See the full show notes for this episode on the website at talkpython.fm 481

   See the full show notes for this episode on the website at talkpython.fm 480

   See the full show notes for this episode on the website at talkpython.fm 479

   See the full show notes for this episode on the website at talkpython.fm 478

   See the full show notes for this episode on the website at talkpython.fm 477